ABSTRACT
Objective To investigate the clinical effect of caffeic acid tablets on hypocytosis induced by radiotherapy in patients with lung cancer. Methods From January 2017 to October 2015,one hundred and twenty patients with lung cancer treated by radiotherapy in No. 88 Hospital of PLA were selected and randomly divided into the observation group and the control group,60 cases in each group. Patients in the observation group were treated by oral caffeic acid tablets 0. 3 g/time,3 times/d until the end of radiotherapy. The control group was treated with radiotherapy alone and did not take any blood raising drugs. When myelosuppression appeared, recombinant human granulocyte colony-stimulating factor Injection or recombinant human interleukin 11 was given till it turned to normal blood. The incidence rate of bone marrow suppression,number of white blood cells (WBC),platelet (PLT) and the efficacy of radiotherapy were observed. Results The incidence rate of bone marrow suppression of the observation group was 16. 67％( 10/60) ,which was significantly lower than that of the control group ( 63. 33％( 38/60 ) ) . The difference was statistically significant (χ2 = 27. 22, P<0. 05 ); the incidence of bone marrow inhibition in the observation group was 0,while the control group was 15. 00％ (9/60) ,and the difference was statistically significant (χ2=9. 73,P<0. 05) . The number of white blood cells and platelets decreased significantly in the two groups after radiotherapy. The number of leukocytes and platelets in the observation group at 1,2,3 and 4 weeks after radiotherapy were significantly higher than those in the control group,the difference was statistically significant (P<0. 05). The effective rate of radiotherapy was 70. 00％ (42/60) in the observation group and 66. 67％ (40/60) in the control group,with no significant difference (χ2=0. 15,P>0. 05) . Conclusion Caffeic acid tablet is effective in preventing leukocyte and thrombocytopenia caused by bone marrow suppression in patients with lung cancer after radiotherapy.
ABSTRACT
The aim of this study was to evaluate the role of vascular endothelial growth factor (VECF) and its receptor flk-1 system in angiogenesis and progression of human hepatocellular carcinoma (HCC) in vivo, the flk-1 dominant-negative mutant was cloned into the retroviral expression vector pLXSN, and was then packaged by PA317 cells to produce ecotropic retroviruses expressing mutated receptor constructs. 50mm_3 of LCI D-20 intact tissue were subcutaneously or orthotopically implanted in nude mice respectively. At day 1,3,5 after implantation, growing tumor were injected with 0.1 ml retroviral supematants into the site of tumor implantation. Tumor volumes, vascular density and lung metastasis were investigated. The results showed that the transfectants by flk-1 TM formed very small tumors after 21 days, which were less than 10 folds in size compared with control. There were hardly visible vessels in flk-1 TM transfected tumor tissue, whereas rich neovascularization could be found in control. The metastatic nodules in lungs were markedly decreased by dominant-negative flk-l TM (P